Tirz vs Reta vs Sema: What the Names Mean

You'll see these three short names everywhere. Here's what each one stands for.

Sema = semaglutide

It acts on one receptor, GLP-1. Prescription brands: Ozempic and Wegovy. Sema 5mg.

Tirz = tirzepatide

It acts on two receptors, GIP and GLP-1. Prescription brands: Mounjaro and Zepbound. Tirz vials.

Reta = retatrutide

It acts on three receptors: GIP, GLP-1 and glucagon. Still in trials, with no approved brand. Reta vials.

The easy way to remember

One receptor, two, then three: Sema, Tirz, Reta. For the full side by side, see Tirz vs Reta.

Research use

Single Vial Peptides lists Sema, Tirz and Reta as laboratory research powders, never for people or animals. This page compares names only and gives no dosing.

Vials mentioned in this guide

Tirz (Tirzepatide) 10mg · $35.00
Reta (Retatrutide) 10mg · $50.00
Sema (Semaglutide) 5mg · $35.00

Research vials. 21 and older. Not for people or animals. Not medical advice.